פרופ' סילביה קוטון

Stroke epidemiology, aging and cognitive function

From her early days in research, Prof. Koton focused on studying stroke and its epidemiological aspects. This led her to delve deeper into the health conditions related to stroke and aging, including changes in physical, cognitive, and social function. Recognizing the need to address the specific needs of the elderly, she became passionate about aging research. This personal journey equipped her  with valuable insights that contribute to her work at the Herczeg Institute.

Stroke is a major cause of long-term disability and a strong predictor of dementia and cognitive decline in adult and elderly populations. The incidence of stroke has declined in the last decades in various countries, however, this decline is not consistent across population-groups.

Prof. Koton's varied research includes studies on epidemiology of stroke and other cardiovascular diseases; age and aging; dementia, changes in physical and cognitive functioning after stroke, and health of primary caregivers of the elderly.

Prof. Silvia Koton studies the factors associated with changes in stroke epidemiology and cardiovascular risk factors in Israel and in the US. Her research provides important information on possible reasons for these changes; how the incidence of stroke may be affected by the increasing rates of obesity, diabetes and other cardiovascular risk factors, and how the changing trends in stroke may influence rates of physical and cognitive function in old persons.

Selected Publications (last 5 years only)

Commodore-Mensah Y, Mok Y, Gottesman RF, Kucharska-Newton A, Matsushita K, Palta P, Rosamond WD, Sarfo FS, Coresh J, Koton S. Life's Simple 7 at Midlife and Risk of Recurrent Cardiovascular Disease and Mortality after Stroke: The ARIC study. J Stroke Cerebrovasc Dis. 2022 Apr 22;31(7):106486. doi: 10.1016/j.jstrokecerebrovasdis.2022.106486. Epub ahead of print. PMID: 35468496.

Ghelani KP, Chen LY, Norby FL, Soliman EZ, Koton S, Alonso A. Thirty-Year Trends in the Incidence of Atrial Fibrillation: The ARIC Study. J Am Heart Assoc. 2022 Apr 19;11(8):e023583. doi: 10.1161/JAHA.121.023583. Epub 2022 Apr 12. PMID: 35414195.

Eizenberg Y, Grossman E, Tanne D, Koton, S. Admission hydration status and ischemic stroke outcome- Experience from a national registry of hospitalized stroke patients. J Clin Med 2021, 10, 3292. https://doi.org/10.3390/ jcm10153292

Mok Y, Ballew S, Stacey R, Rossi J, Koton S, Kucharska-Newton A, Chang P, Coresh J, Rosamond WD, Matsushita K. Albuminuria and prognosis among individuals with atherosclerotic cardiovascular disease: the ARIC study. JACC 2021; 78:87-89. doi: 10.1016/j.jacc.2021.04.089.

Gendler Y (S), Birk E, Tabak N, Koton S. Factors influencing the parental decision making regarding termination of pregnancy following prenatal diagnosis of congenital heart disease: A prospective study. JOGNN-J Obst Gyn Neo 2021; 50:475-484.

Murthy SB, Zhang C, Diaz I, Levitan EB, Koton S, Bartz TM, DeRosa JT, Strobino K, Colantonio L, Iadecola C, Monika M. Safford MM, Howard VJ, Longstreth WT, Gottesman RF; Sacco RL, Elkind MSV, Howard G, Kamel H. Association Between Intracerebral Hemorrhage and Subsequent Arterial Ischemic Events in ARIC, CHS, NOMAS, and REGARDS. JAMA Neurol. 2021; 78:809-816. doi: 10.1001/jamaneurol.2021.0925.

Mediano MFF, Mok Y, Coresh J, Kucharska-Newton A, Palta P, Lakshminarayan K, Rosamond WD, Matsushita K, Koton S. Prestroke Physical Activity and Adverse Health Outcomes After Stroke in the Atherosclerosis Risk in Communities Study. Stroke 2020, https://doi.org/10.1161/STROKEAHA.120.032695

Foti K, Matsushita K, Koton S, Walker KA, Coresh J, Appel LJ, Selvin E. Changes in hypertension control in a community-based population of older adults, 2011-2013 to 2016-2017. Am J Hypertens. 2020 Dec 5:hpaa206. doi: 10.1093/ajh/hpaa206.

Ruban A, Daya N, Schneider ALC, Gottesman RF, Selvin E, Coresh J, Lazo M, Koton S. Liver enzymes and risk of stroke: The Atherosclerosis Risk in Communities Study (ARIC). J Stroke. 2020;22(3):357-368. doi: 10.5853/jos.2020.00290.

Koton S, Schneider ALC, Windham BG, Mosley T, Gottesman RF, Coresh J. Microvascular brain disease progression and risk of stroke: The Atherosclerosis Risk in Communities (ARIC) Study. Stroke 2020, 1 Oct 2020; https://doi.org/10.1161/STROKEAHA.120.030063

Shmilovitz R (S), Itzhaki M, Koton S. Associations between gender, sex-types and caring behaviors among nurses in mental. J Psychiatr Ment Health Nurs 2020;00:1–8. https://doi.org/10.1111/jpm.12694

Mok Y, Ballew SH, Stacey B, Rossi J, Koton S, Kucharska-Newton A, Chang PP, Coresh J, Rosamond W, Matsushita K. Prognostic variation among very high-risk and high-risk individuals with atherosclerotic cardiovascular disease. JACC 2020; 76:346-348.

Scheppach JB, Coresh J, Wu A, Gottesman RF, Mosley TH, Knopman DS, Grams ME, Sharrett AR, Koton S. Albuminuria and estimated GFR as risk factors of dementia in midlife and older age: Findings from the ARIC Study. Am J Kidney Dis.2020 May 16:S0272-6386(20)30689-2. doi: 10.1053/j.ajkd.2020.03.015. Online ahead of print.

Wang SY, Tan ASL, Claggett B, Chandra A, Khatana SAM, Lutsey PL, Kucharska-Newton A, Koton S, Solomon SD, Kawachi I; for the ARIC investigators. Longitudinal associations between income changes and incident cardiovascular disease: The Atherosclerosis Risk in Communities Study. JAMA Cardiol.2019 Oct 9. doi: 10.1001/jamacardio.2019.3788. [Epub ahead of print]. 

Koton S, Sang Y, Schneider ALC, Rosamond WD, Gottesman RF, Coresh J. Trends in stroke incidence in older US adults: An update from the Atherosclerosis Risk in Communities (ARIC) cohort study. JAMA Neurol.2019 Sep 30. doi: 10.1001/jamaneurol.2019.3258. [Epub ahead of print].

Miaary Z, Tanne D, Koton S. Functional impairment three months after acute stroke: Patient reported outcomes in the National Acute Stroke Israeli registry-NASIS 2016.Harefuah.2019;158:367-371.Invited original paper. Special issue of “Harefuah” on Brain Health (Hebrew).

Schneider ALC, Selvin E, Liang M, Latour L, Turtzo LC, Koton S, Coresh J, Mosley T, WhitlowCT, Zhou Y, Wong D, Ling G, Gottesman RF. Association of head injury with brain amyloid deposition: The ARIC-PET Study. J Neurotrauma.2019 Apr 9. doi: 10.1089/neu.2018.6213.

Florido R, Lee AK, McEvoy JW, Hoogeveen RC, Koton S, Vitolins MZ, Shenoy C, Russell SD, Blumenthal RS, Ndumele CE, Ballantyne CM, Joshu CE, Platz EA, Selvin E. Cancer survivorship and subclinical myocardial damage: The ARIC Study. Am J Epidemiol.2019 Mar 30. pii: kwz088.doi: 10.1093/aje/kwz088.

Koton S, Wruck L, Quibrera PM, Gottesman RF, Agarwal SK, Jones S, Wright JD, Shahar E,Coresh J, Rosamond WD.Temporal trends in validated ischaemic stroke hospitalizations in the USA. Int J Epidemiol.2019 Mar 16. pii: dyz025. doi:10.1093/ije/dyz025.

Koton S, Geva D, Streifler JY, Harnof S, Pougach Y, Azrilin O, Hadar S, Bornstein NM, Tanne D. Declining rate and severity of hospitalized stroke from 2004 to 2013: The National Acute Stroke Israeli Registry. Stroke. 2018; 49:1348-1354.

Eizenberg Y, Grossman E, Tanne D, Koton S. Pre admission treatment with Beta-blockers in hypertensive patients with acute stroke and 3-month outcome-Data from a national stroke registry. Journal of clinical hypertension (Greenwich, Conn.). 2018; 20(3):568-572.

Melnikov S, Itzhaki M, Koton S. Age-group and gender differences in stroke knowledge in an Israeli Jewish adult population. The Journal of cardiovascular nursing. 2018; 33(1):55-61.

Peretz S, Orion D, Last D, Mardor Y, Kimmel Y, Yehezkely S, Lotan E, Itsekson-Hayosh Z, Koton S, Guez D, Tanne D. Incorporation of relative cerebral blood flow into CT perfusion maps reduces false 'at risk' penumbra. Journal of neurointerventional surgery. 2017; PMID: 28965105

Koton S, Rexrode KM. Trends in stroke incidence in the United States: Will women overtake men? Neurology. 2017; 89(10):982-983.

Windham BG, Harrison KL, Lirette ST, Lutsey PL, Pompeii LA, Gabriel KP, Koton S, Steffen LM, Griswold ME, Mosley TH Jr. Relationship between midlife cardiovascular health and late-life physical performance: The ARIC Study. Journal of the American Geriatrics Society. 2017; 65(5):1012-1018.

Koton S, Tanne D, Grossman E. Prestroke treatment with beta-blockers for hypertension is not associated with severity and poor outcome in patients with ischemic stroke: data from a national stroke registry. Journal of hypertension. 2017; 35(4):870-876.

Kucharska-Newton A, Griswold M, Yao ZH, Foraker R, Rose K, Rosamond W, Wagenknecht L, Koton S, Pompeii L, Windham BG. Cardiovascular disease and patterns of change in functional status over 15 years: Findings fom the Atherosclerosis Risk in Communities (ARIC) Study. Journal of the American Heart Association. 2017; 6(3).

Melnikov S, Itzhaki M, Koton S. Differences between new immigrants from the former Soviet Union and veteran residents in knowledge, perception, and risk factors of stroke. The Journal of cardiovascular nursing. 2016; 31(6):500-506.

Itzhaki M, Melnikov S, Koton S. Gender differences in feelings and knowledge about stroke. Journal of clinical nursing. 2016; 25(19-20):2958-66.

Kipnis G, Tabak N, Koton S. Background music playback in the preoperative setting: Does It reduce the level of preoperative anxiety among candidates for elective surgery? Journal of perianesthesia nursing: official journal of the American Society of PeriAnesthesia Nurses. 2016; 31(3):209-16.

Eizenberg Y, Koton S, Tanne D, Grossman E. Association of age and admission mean arterial blood pressure in patients with stroke-data from a national stroke registry. Hypertension research: official journal of the Japanese Society of Hypertension. 2016; 39(5):356-61.

Cobb LK, Godino JG, Selvin E, Kucharska-Newton A, Coresh J, Koton S. Spousal influence on physical activity in middle-aged and older adults: The ARIC Study. American journal of epidemiology. 2016; 183(5):444-51.

Koton S, Eizenberg Y, Tanne D, Grossman E. Trends in admission blood pressure and stroke outcome in patients with acute stroke and transient ischemic attack in a National Acute Stroke registry. Journal of hypertension. 2016; 34(2):316-22.